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  • Published research highlights new modes of action
  • Discovered non-Bt protein could be a critical component in managing corn rootworm
  • RNA interference discovery also demonstrating efficacy for protection from corn rootworms
DuPont Pioneer researchers have discovered a protein from a non-Bacillus thuringiensis (Bt) bacterium source that exhibits promise as an alternative means for controlling corn rootworm in North America and Europe. Science Magazine published the finding this week.

“This research represents a breakthrough for addressing a major challenge in agriculture,” said Neal Gutterson, vice president, Research & Development, DuPont Pioneer. “We have discovered a non-Bt protein that demonstrates insecticidal control of western corn rootworm with a new and different mode of action than Bt proteins currently used in transgenic products. This protein could be a critical component for managing corn rootworm in future corn seed product offerings. The work also suggests that bacteria other than Bt are alternative sources of insecticidal proteins for insect control trait development.”

An extremely destructive corn pest, corn rootworm larvae and adults can cause significant economic loss for growers. The current biotech approach for insect control sources proteins from Bt soil bacteria. Field-evolved insect resistance to certain Bt proteins has been observed in some geographies.

Another Pioneer study related to non-Bt insect control, recently published in Scientific Reports, shows how RNA interference (RNAi) can be applied to control corn rootworm feeding damage.

RNAi is a biologically occurring process that happens in the cells of plants, animals and people. By employing the RNAi process, a plant can protect itself by carrying instructions that precisely target specific proteins in pests.

“Growers need a next generation of solutions to help protect their crops. Our researchers are developing innovative, new modes for insect control to help meet future demands. Non-Bt proteins and RNA-based products highlight our efforts to identify alternative methods for effective control of insect feeding damage in agriculture,” Gutterson said.

Pioneer is committed to delivering superior germplasm, native and biotech traits, seed treatments and agronomic advice for the most productive products to its customers. Pioneer has a robust product pipeline. Maintaining trait durability and promoting world-class stewardship practices are among its top priorities.

DuPont Pioneer is the world's leading developer and supplier of advanced plant genetics, providing high-quality seeds to farmers in more than 90 countries. Pioneer provides agronomic support and services to help increase farmer productivity and profitability and strives to develop sustainable agricultural systems for people everywhere. Science with Service Delivering Success®.

DuPont (NYSE: DD) has been bringing world-class science and engineering to the global marketplace in the form of innovative products, materials, and services since 1802. The company believes that by collaborating with customers, governments, NGOs, and thought leaders, we can help find solutions to such global challenges as providing enough healthy food for people everywhere, decreasing dependence on fossil fuels, and protecting life and the environment. For additional information about DuPont and its commitment to inclusive innovation, please visit